Niacin

[aeon]

http://orthomolecular.org/history/hoffer/index.shtml

http://www.doctoryourself.com/hoffer_niacin.html

http://www.orthomolecularvitamincentre. ... hrenia.php


http://www.altmedrev.com/publications/13/4/287.pdf

http://www.orthomolecular.org/history/hoffer/ahlife.pdf

http://www.sdadefend.com/Health/Niacine.pdf

[Ye Admin]

So what's the best brand of niacin to buy? You seem fond of Twinlabs.

[aeon]

I like niacin as the powder or in capsules. Tablets have fillers.

I would not get nicotinic acid - the flushing niacin - in a larger size than 100 mgs. 500 or 1000 mgs capsule is too much. I never could take more than 300 mgs of nicotinic acid a day. Niacinamide can still make you flush a little in the 1 - 3 gram dose. Niacinamide can be taken as 100 mg capsules or 500 mg capsules.

Never ever get time released niacin it damages the liver.

Basically I go with companies I trust. I read the labels and the customer reviews.

Now Foods has generally good products.

https://www.iherb.com/pr/Now-Foods-Niac ... psules/704

[aeon]

http://blog.healthybynaturehwc.com/niacin-deficiency/

http://www.orthomolecularvitamincentre. ... cancer.php

http://orthomolecular.org/resources/omns/v04n25.shtml

http://www.orthomolecularvitamincentre.com/aging.php

http://www.alternative-cancer-care.com/ ... otocol.pdf

[aeon]

http://www.lifeextension.com/magazine/2 ... td/Page-01

https://livertox.nih.gov/Niacin.htm

https://boltonsmokersclub.wordpress.com ... inic-acid/

[Ye Admin]

I ended up getting the non-flushing kind and it seems to benefit my wife a lot. But, I've been suffering from progressively worse depression since a month or so ago and the niacinimide appears to not do much for it.

I found at least one site saying to try the flushing kind. http://mightyambitions.com/niacin-for-depression/
I'm not sure if it will work but it could be worth a try.

[aeon]

Niacinamide can actually increase depression if you already have it. Nicotinic acid does not. You only need to take a 100 mgs a day of nicotinic to see if it helps. Other than coffee the best thing I have tried is magnesium around 350 mgs a day. The other thing is too much salt or other sodium compounds can increase depression. A compounding problem may be Lunesta because being a GABA receptor agonist it produces typically sedative effects that can persist during the daytime manifesting as depression.

http://www.livestrong.com/article/46169 ... epression/

[Ye Admin]

Wow!! Thank you for clearing that up. Lately I've been far too depressed and foggy to research this for myself. I ordered the nicotinic Twinlabs caps, let's see how that goes.

[aeon]

https://www.drugs.com/slideshow/grapefr ... tions-1028

I first heard about this effect in the 90s. I still think that is a strange effect that would not occur to someone without being warned.

[aeon]

In 1987 I read that taking niacinamide and inositol could sedate you as good as Ativan by binding to the same receptor sites. Now nicotinic acid has a much weaker binding effect and by burning up some histamine reduces depression.

In the late 1970s niacinamide was reported to be a ligand for the benzodiazepine receptor with physiological activities. Later studies suggested that the effect is not based on a direct specific interaction between niacinamide and benzodiazepine receptors.

However, ten years later a completely different benzodiazepine-binding receptor was identified in the peripheral nervous system.

This peripheral benzodiazepine receptor, known as translocator protein (TSPO), can modulate neurosteroids, which can alter neuronal excitability through interactions with GABA neurotransmitter ion channels. This can enhance GABA receptor function.

http://www.nature.com/nature/journal/v2 ... 563a0.html

https://www.ncbi.nlm.nih.gov/pubmed/9229848

https://www.ncbi.nlm.nih.gov/pubmed/6090200